The trail of chromium(III) in vivo from the blood to the urine: the roles of transferrin and chromodulin

@article{Clodfelder2001TheTO,
  title={The trail of chromium(III) in vivo from the blood to the urine: the roles of transferrin and chromodulin},
  author={Buffie J. Clodfelder and Juliet A Emamaullee and Dion D. D. Hepburn and Nicole E. Chakov and Heather S. Nettles and John B. Vincent},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2001},
  volume={6},
  pages={608-617}
}
The chromium-binding oligopeptide chromodulin (also known as low-molecular-weight chromium-binding substance) has been shown to activate the tyrosine kinase activity of the insulin receptor in response to insulin and has been proposed to be part of a novel autoamplification mechanism for insulin signaling. The model requires that Cr3+ be moved from the blood to insulin-sensitive tissues in response to insulin and subsequently be lost in the urine as chromodulin; however, the model has not been… 
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