The trafficking and targeting of P2X receptors

  title={The trafficking and targeting of P2X receptors},
  author={Lucy E. Robinson and R. D. Murrell-Lagnado},
  journal={Frontiers in Cellular Neuroscience},
  • Lucy E. Robinson, R. D. Murrell-Lagnado
  • Published 2013
  • Biology, Medicine
  • Frontiers in Cellular Neuroscience
  • The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very different trafficking properties. Some are retained within the endoplasmic reticulum (ER), while others are predominantly at the cell surface or within endosomes and lysosomes. Changes in recruitment of receptors to and from the plasma membrane… CONTINUE READING
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