The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide production.

@article{Wang2009TheTO,
  title={The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide production.},
  author={Hong Wang and Aileen X. Wang and Zhen-qi Liu and Weidong Chai and Eugene J. Barrett},
  journal={Molecular endocrinology},
  year={2009},
  volume={23 10},
  pages={1613-23}
}
Endothelial nitric oxide synthase (eNOS) activity is tightly regulated by posttranscriptional modification and its subcellular localization. Here we examined whether insulin modulates nitric oxide (NO) production by regulating eNOS subcellular localization. We used confocal microscopy and immunoblots to examine the time course for 1) subcellular targeting/association of eNOS and caveolin-1 (CAV-1); 2) eNOS Ser(1179) phosphorylation; and 3) NO production in cultured bovine aorta endothelial… CONTINUE READING
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