The toxin of diarrheic shellfish poisoning, okadaic acid, increases intestinal epithelial paracellular permeability.

@article{Tripuraneni1997TheTO,
  title={The toxin of diarrheic shellfish poisoning, okadaic acid, increases intestinal epithelial paracellular permeability.},
  author={J Tripuraneni and Athanasia Koutsouris and L Pestic and Primal de Lanerolle and Gail A. Hecht},
  journal={Gastroenterology},
  year={1997},
  volume={112 1},
  pages={100-8}
}
BACKGROUND & AIMS Diarrhea associated with shellfish poisoning is poorly understood. The responsible toxin, dinophysistoxin 1, has been identified as okadaic acid, a potent phosphatase inhibitor, but its effects on intestinal epithelia have not been examined. The aim of this study was to investigate the effect of okadaic acid on intestinal epithelial function, both Cl- secretion and barrier function. METHODS Cultured human intestinal epithelial T84 cell monolayers were used. The effect of… CONTINUE READING
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