The toxicology of chromium with respect to its chemical speciation: A review

  title={The toxicology of chromium with respect to its chemical speciation: A review},
  author={Sidney A. Katz and Harry Salem},
  journal={Journal of Applied Toxicology},
  • S. Katz, H. Salem
  • Published 1 May 1993
  • Chemistry
  • Journal of Applied Toxicology
The properties of trivalent and hexavalent chromium are reviewed with respect to acute and chronic oral toxicity, dermal toxicity, systemic toxicity, toxicokinetics, cytotoxicity, genotoxicity and carcinogenicity. The hexavalent chromium compounds appear to be 10–100 times more toxic than the trivalent chromium compounds when both are administered by the oral route. Dermal irritancy and allergy are more frequently caused by contact with soluble hexavalent chromium compounds. The cytotoxicity of… 
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Biochemical speciation in chromium genotoxicity
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