The toxicology of benzene.

  title={The toxicology of benzene.},
  author={Robert Snyder and Gisela Witz and Bernard David Goldstein},
  journal={Environmental Health Perspectives},
  pages={293 - 306}
Benzene is metabolized, primarily in the liver, to a series of phenolic and ring-opened products and their conjugates. The mechanism of benzene-induced aplastic anemia appears to involve the concerted action of several metabolites acting together on early stem and progenitor cells, as well as on early blast cells, such as pronormoblasts and normoblasts to inhibit maturation and amplification. Benzene metabolites also inhibit the function of microenvironmental stromal cells necessary to support… CONTINUE READING


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