The toxicological significance of xenobiotic metabolism.

@article{Caldwell1990TheTS,
  title={The toxicological significance of xenobiotic metabolism.},
  author={John Caldwell and A. J. Howes and Sharon A.M. Hotchkiss},
  journal={Food additives and contaminants},
  year={1990},
  volume={7 Suppl 1},
  pages={
          S116-26
        }
}
Summary In conclusion, these and similar data illustrate the usefulness of metabolic information in the specific context of the safety assessment of natural food flavours (JECFA 1987). This type of data not only aids the interpretation of toxicity tests, making it possible to devise soundly‐based mathematical models for the assessment of the implications for human health of the consumption of allylbenzenes and other dietary toxicants but also permits the design of more relevant tests. In… 
An Introduction to Drug Disposition: The Basic Principles of Absorption, Distribution, Metabolism, and Excretion
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This presentation is intended to provide an introductory overview of the life cycle of a drug in the animal body and indicates the significance of such information for a full understanding of mechanisms of action and toxicity.
Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism‐dependent haptenation and T‐cell proliferation in vivo
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