The toxicological significance of xenobiotic metabolism.

  title={The toxicological significance of xenobiotic metabolism.},
  author={John Caldwell and A. J. Howes and Sharon A.M. Hotchkiss},
  journal={Food additives and contaminants},
  volume={7 Suppl 1},
Summary In conclusion, these and similar data illustrate the usefulness of metabolic information in the specific context of the safety assessment of natural food flavours (JECFA 1987). This type of data not only aids the interpretation of toxicity tests, making it possible to devise soundly‐based mathematical models for the assessment of the implications for human health of the consumption of allylbenzenes and other dietary toxicants but also permits the design of more relevant tests. In… 
An Introduction to Drug Disposition: The Basic Principles of Absorption, Distribution, Metabolism, and Excretion
This presentation is intended to provide an introductory overview of the life cycle of a drug in the animal body and indicates the significance of such information for a full understanding of mechanisms of action and toxicity.
Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism‐dependent haptenation and T‐cell proliferation in vivo
The antigenicity of nitroso sulphamethoxazole in vivo is demonstrated and evidence for the role of drug metabolism and cell surface haptenation in the induction of a cellular immune response in the rat is provided.


Metabolism of estragole in rat and mouse and influence of dose size on excretion of the proximate carcinogen 1'-hydroxyestragole.
  • A. Anthony, J. Caldwell, A. Hutt, R. Smith
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1987
Chronic toxicity/carcinogenicity study of trans-anethole in rats.
Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.
Twenty-three naturally occurring and synthetic alkenylbenzene derivatives structurally related to the hepatocarcinogen safrole were assayed for their hepatocARCinogenicity in mice to identify benign skin tumors that could be promoted with croton oil.
The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers.
1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using the
Clinical Pharmacokinetics of Methyldopa
There is a marked accumulation of unidentified metabolites in renal failure patients, which possibly explains the strong and prolonged hypotensive action of methyldopa in these patients.
Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver.
Data strongly support the conclusion that 1'-sulfoöxysafrole is the major ultimate electrophilic and tumor-initiating metabolite of 1'-hydroxysaf role.