The toxicological evaluation of the mycotoxins T-2 and T-2 tetraol using normal human fibroblasts in vitro.

@article{Oldham1980TheTE,
  title={The toxicological evaluation of the mycotoxins T-2 and T-2 tetraol using normal human fibroblasts in vitro.},
  author={James W. Oldham and Lawrence E. Allred and George E. Milo and O R Kindig and Charles C. Capen},
  journal={Toxicology and applied pharmacology},
  year={1980},
  volume={52 1},
  pages={
          159-68
        }
}
Multiparametric evaluation of the toxic responses of normal human cells treated in vitro with different classes of environmental toxicants.
TLDR
It is concluded that similarities in survival responses of cells to closely related toxicants may arise frequently through toxic action at different sites within the cells.
Effects of T-2 mycotoxin on gastrointestinal tissues: A Review ofin vivo andin vitro models
  • P. Williams
  • Biology
    Archives of environmental contamination and toxicology
  • 1989
TLDR
A host of bioassay systems are now being used as alternative methods to the use of animals for testing of the mycotoxin, which promotes a chemically-induced change in structure and function of affected gastrointestinal cells from a transient and reversible aberration in a single enzyme reaction to cell death.
Ultrastructural effects of T-2 mycotoxin on rat hepatocytes in vitro.
  • L. R. Trusal, J. O'Brien
  • Biology, Medicine
    Toxicon : official journal of the International Society on Toxinology
  • 1986
Cytotoxicity Evaluation of Mycotoxins by an MTT-Bioassay
TLDR
The modified MTT cleavage assay was found to be a quick and efficient colorimetric test for examining the cytotoxicity of three mycotoxins and indicates, that the massive cytotoxic effect of the mycotoxin deoxynivalenol is more likely to be an unspecific than a specific one.
TOXIC EFFECTS OF T-2 TOXIN ON THE PRIMARY HEPATOCYTE CULTURE FROM MICE
TLDR
The effects of T-2 toxin on hepatocytes were investigated in vitro and degeneration of rER, deformation of mitochondria, and formation of autosegrisomes developed at 6hr and became more prominent at 24hr.
Cytotoxic and immunotoxic effects of Fusarium mycotoxins using a rapid colorimetric bioassay
TLDR
A colorimetric MTT (tetrazolium salt) cleavage test was used to evaluate cytotoxicity of Fusarium mycotoxins on two cultured human cell lines as well as their inhibitory effect on proliferation of phytohemagglutinin-stimulated human peripheral blood lymphocytes.
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References

SHOWING 1-10 OF 14 REFERENCES
Cell culture as a test system for toxicity
  • S. Metcalfe
  • Biology
    The Journal of pharmacy and pharmacology
  • 1971
TLDR
It is suggested that the ability of the food additive butylated hydroxytoluene to act as a potent inhibitor of cellular growth may account for its reported ability to prolong the life span of mice.
Mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbons.
TLDR
It is demonstrated that metabolic activation of polycyclic hydrocarbon is required for mutagenic activity in mammalian cells.
Biochemical activation of aryl hydrocarbon hydroxylase activity, cellular distribution of polynuclear hydrocarbon metabolites, and DNA damage by polynuclear hydrocarbon products in human cells in vitro.
TLDR
It was concluded that benzo(a)pyrene can initiate all the biochemical events in human cells probably necessary to initiate transformation of human cells in vitro.
Quantitation of chemically induced neoplastic transformation of BALB-3T3 cloned cell lines.
TLDR
Recloned, carcinogen-sensitive, BALB/3T3 cell lines present a reliable in vitro quantitative bioassay model for the study of chemical carcinogenesis.
HISTOCHEMICAL AND ULTRASTRUCTURAL DEMONSTRATION OF γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY
TLDR
The optimum conditions for the histochemical reaction were developed and the distribution of enzymatic activity in the tissues of the rat is described for light microscopy and with rat pancreas for electron microscopy.
...
1
2
...