The toxicological evaluation of the mycotoxins T-2 and T-2 tetraol using normal human fibroblasts in vitro.

@article{Oldham1980TheTE,
  title={The toxicological evaluation of the mycotoxins T-2 and T-2 tetraol using normal human fibroblasts in vitro.},
  author={James W. Oldham and Lawrence E. Allred and George E. Milo and O R Kindig and Charles C. Capen},
  journal={Toxicology and applied pharmacology},
  year={1980},
  volume={52 1},
  pages={
          159-68
        }
}
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67 Citations
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67 Citations

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Citation Type

Multiparametric evaluation of the toxic responses of normal human cells treated in vitro with different classes of environmental toxicants.
TLDR
It is concluded that similarities in survival responses of cells to closely related toxicants may arise frequently through toxic action at different sites within the cells.
Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture.
Effects of T-2 mycotoxin on gastrointestinal tissues: A Review ofin vivo andin vitro models
  • P. Williams
  • Biology
    Archives of environmental contamination and toxicology
  • 1989
TLDR
A host of bioassay systems are now being used as alternative methods to the use of animals for testing of the mycotoxin, which promotes a chemically-induced change in structure and function of affected gastrointestinal cells from a transient and reversible aberration in a single enzyme reaction to cell death.
Toxicity of T-2 toxin, a Fusarium mycotoxin, to alveolar macrophages in vitro.
Ultrastructural effects of T-2 mycotoxin on rat hepatocytes in vitro.
  • L. R. Trusal, J. O'Brien
  • Biology, Medicine
    Toxicon : official journal of the International Society on Toxinology
  • 1986
In vivo effects of T-2 mycotoxin on synthesis of proteins and DNA in rat tissues.
The effects of T-2 toxin on alveolar macrophage function in vitro.
Cytotoxicity Evaluation of Mycotoxins by an MTT-Bioassay
TLDR
The modified MTT cleavage assay was found to be a quick and efficient colorimetric test for examining the cytotoxicity of three mycotoxins and indicates, that the massive cytotoxic effect of the mycotoxin deoxynivalenol is more likely to be an unspecific than a specific one.
TOXIC EFFECTS OF T-2 TOXIN ON THE PRIMARY HEPATOCYTE CULTURE FROM MICE
TLDR
The effects of T-2 toxin on hepatocytes were investigated in vitro and degeneration of rER, deformation of mitochondria, and formation of autosegrisomes developed at 6hr and became more prominent at 24hr.
Cytotoxic and immunotoxic effects of Fusarium mycotoxins using a rapid colorimetric bioassay
TLDR
A colorimetric MTT (tetrazolium salt) cleavage test was used to evaluate cytotoxicity of Fusarium mycotoxins on two cultured human cell lines as well as their inhibitory effect on proliferation of phytohemagglutinin-stimulated human peripheral blood lymphocytes.
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