The toxicity of thallium(I) to cardiac and skeletal muscle.

  title={The toxicity of thallium(I) to cardiac and skeletal muscle.},
  author={M. Hughes and W. Man and B. Whaler},
  journal={Chemico-biological interactions},
  volume={23 1},
  • M. Hughes, W. Man, B. Whaler
  • Published 1978
  • Chemistry, Medicine
  • Chemico-biological interactions
  • The effects of (a) partial or complete replacement of K+ by Tl+ in saline perfusing isolated rat heart and diaphragm preparations and (b) pulse injections of high concentrations of Tl+ or K+, have been studied. The immediate effect of Tl+ resembles that of higher concentrations of K+ and may reflect its more rapid penetration into the tissue. Tl+ appears to replace K+ on a 1:1 basis to an extent dependent upon the relative abundance of the two cations in the perfusion solution. However… CONTINUE READING
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