The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

@inproceedings{Pritchard2011TheTO,
  title={The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics},
  author={Susanne M. Pritchard and Philip J. Dolan and Alisa Vitkus and Gail V. W. Johnson},
  booktitle={Journal of cellular and molecular medicine},
  year={2011}
}
It has been almost 25 years since the initial discovery that tau was the primary component of the neurofibrillary tangles (NFTs) in Alzheimer disease (AD) brain. Although AD is defined by both β-amyloid (Aβ) pathology (Aβ plaques) and tau pathology (NFTs), whether or not tau played a critical role in disease pathogenesis was a subject of discussion for many years. However, given the increasing evidence that pathological forms of tau can compromise neuronal function and that tau is likely an… CONTINUE READING

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