The toxicity of Escherichia coli L-asparaginase.

  title={The toxicity of Escherichia coli L-asparaginase.},
  author={Philip S. Schein and Nathan Rakieten and Barry Monroe Gordon and Ruth D. Davis and David P. Rall},
  journal={Cancer research},
  volume={29 2},
Summary l-Asparaginase-containing extracts from Escherichia coli have undergone toxicologic evaluation in mice, guinea pigs, rabbits, beagle dogs, and Rhesus monkeys. The preparation elicited acute anaphylaxis in sensitized guinea pigs and produced precipitating antibodies in one of six rabbits. In five of nine batches, temperature elevations of one degree Fahrenheit or more, associated with leukocytosis, were observed in the monkey. With continued treatment the monkey demonstrated varying… CONTINUE READING