The toxicity and teratogenicity of mercuric mercury in the pregnant rat

@article{Holt2004TheTA,
  title={The toxicity and teratogenicity of mercuric mercury in the pregnant rat},
  author={Daphne Holt and Michael Webb},
  journal={Archives of Toxicology},
  year={2004},
  volume={58},
  pages={243-248}
}
  • D. Holt, M. Webb
  • Published 1 April 1986
  • Medicine, Biology
  • Archives of Toxicology
Mercuric mercury (Hg2+), when injected IV into the pregnant Wistar rat, is retained mainly in the maternal compartment and uptake by the conceptuses is small. Thus if the dose is based on total body weight, the maternal body burden, particularly in late gestation, is greater than the whole body burden in the non-pregnant animal. The LD50 of Hg2+ (mg/kg total body weight), however, remains essentially constant (1.0–1.2 mg Hg2+/kg) throughout pregnancy. It seems, therefore, that the rat becomes… 

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