The toxicity and teratogenicity of mercuric mercury in the pregnant rat

  title={The toxicity and teratogenicity of mercuric mercury in the pregnant rat},
  author={Daphne Holt and Michael Webb},
  journal={Archives of Toxicology},
  • D. Holt, M. Webb
  • Published 1 April 1986
  • Medicine, Biology
  • Archives of Toxicology
Mercuric mercury (Hg2+), when injected IV into the pregnant Wistar rat, is retained mainly in the maternal compartment and uptake by the conceptuses is small. Thus if the dose is based on total body weight, the maternal body burden, particularly in late gestation, is greater than the whole body burden in the non-pregnant animal. The LD50 of Hg2+ (mg/kg total body weight), however, remains essentially constant (1.0–1.2 mg Hg2+/kg) throughout pregnancy. It seems, therefore, that the rat becomes… 

Comparison of some biochemical effects of teratogenic doses of mercuric mercury and cadmium in the pregnant rat

It is concluded that the small amount of Cd2+ that is taken up by the foetus has a direct effect on the synthesis of DNA and protein, whereas Hg2+ primarily affects placental transport processes.

The teratogenicity of cadmium-metallothionein in the rat

It is concluded that the uptake by the conceptus in vivo of either CdMT, or of Cd liberated therefrom, is unlikely to contribute to the teratogenic response and the possibility that limited damage to the maternal kidneys may be sufficient to interfere severely with the homeostasis of the conceptUS is suggested.

Teratogenicity of ionic cadmium in the Wistar rat

In rats of the present (re-derived) Wistar-Porton strain that are dosed either intravenously (i.p.) or intraperitoneally with Cd (1.25 mg/kg body weight) on day 12 of gestation (gd 12), foetal uptake of Cd is at least 6-fold greater than that reported in an earlier study (Webb and Samarawickrama 1981), and the teratogenic response is wider than that observed previously.

Biochemical parameters of pregnant rats and their offspring exposed to different doses of inorganic mercury in drinking water.

Cadmium induced teratogenic effects in developing Mus musculus.

It is concluded that Cadmium concentrations used in present study caused teratogenic and embryotoxic in mice fetuses.

Mercury exacerbates cyclosporin nephrotoxicity in rats

The enhanced nephrotoxicity may be attributed to the increased bioavailability of CsA and an increase in lipid peroxidation after concomitant use of these drugs.

Mitochondrial transduction of ocular teratogenesis during methylmercury exposure.

At least some teratological effects of Hg appear linked with late steps in the heme biosynthesis pathway through the Bzrp, and PK11195, a ligand for these mitochondrial receptors, significantly lessens the risk of microphthalmia, microcephaly, and cleft palate in Hg-poisoned embryos.

Health implications of mercury exposure in children

The relevant literature concerning transplacental and lactational exposure to mercury, taking into account mercury speciation, is reviewed in order to have a critical assessment of its adverse health effects.

Mercury and inorganic mercury compounds

  • Chemistry
  • 2002
positive results fragments, aneuploidies, sister chromatid exchanges, micronu-clei). confounders of a dose-response relationship urinary observed e ff ects. Studies in workers with to mercury(II) and

Mercury Pollution from a Chloralkali Source in a Tropical Lake and Its Biomagnification in Aquatic Biota: Link between Chemical Pollution, Biomarkers, and Human Health Concern

  • P. Rai
  • Environmental Science
  • 2008
ABSTRACT Mercury is a highly toxic heavy metal that can cause adverse ecological and toxicological impacts through the mechanism of biomagnification. Hg accumulation in aquatic biota may thus also



The acute toxicity and teratogenicity of cadmium in the pregnant rat

Until the 16th day of gestation the intravenous LD50 of Cd2+ in the pregnant Wistar‐Porton rat is higher, but not significantly different from that in nulliparous females, but at 20 days it is lower, related to the rapid increase in weight of the conceptuses in late gestation and to the retention of most of the dose in the maternal compartment.

The acute toxicity and teratogenicity of nickel in pregnant rats.

Fetotoxicity of inorganic mercury in the mouse: distribution and effects on nutrient uptake by placenta and fetus.

The effects of Hg on the placental and fetal uptake of four nutrients was studied and Hg caused a dose-dependent decrease in fetal radioactivity as compared to controls 4 hours after administration of 57Co-vitamin B12 to the mother.

Acute effects of cadmium on the pregnant rat and embryo-fetal development.

In rats, of the Wistar-Porton strain, a single intravenous injection of 1.25 mg Cd2+ between days 9 and 15 of gestation results in a high incidence (80% of hydrocephalus, together with other

The influence of administered mass on the subcellular distribution and binding of mercury in rat liver and kidney

The observations suggest that the Hg-binding metallothionein in the kidney was saturated by administered doses greater than 0.55 mg Hg · kg−1, whereas in liver saturation levels of the metal were not reached even at the highest dose tested.

Placental transport and embryonic utilization of essential metabolites in the rat at the teratogenic dose of cadmium

In vivo, the simultaneous injection of Zn2+ at a 2:1 atomic ratio with Cd2+ prevented the inhibition of thymidine incorporation into DNA, which is of prime importance in the teratogenic response.

Prenatal and neonatal toxicology and pathology of heavy metals.

The Influence of Weight and Other Physiological Changes During Pregnancy and Lactation on the Toxicities of Mercury and Cadmium

Weight and other physiological changes during pregnancy and lactation may alter the target organ, the elimination rate, and the whole body concentration of a toxic metal and also confound the use of