The total synthesis of vitamin B12

@article{Woodward1973TheTS,
  title={The total synthesis of vitamin B12},
  author={R. Woodward},
  journal={Pure and Applied Chemistry},
  year={1973},
  volume={33},
  pages={145 - 178}
}
  • R. Woodward
  • Published 1973
  • Chemistry, Medicine
  • Pure and Applied Chemistry
The final stages in the total synthesis of vitamin B12 are reported. It was particularly appropriate, I think, and most pleasant for us this morning to see the splendid film provided by our Russian friends, in which the very successful Symposium at Riga was enshrined for posterity. Appropriate in the sense, from my own point of view, that I did report there at Riga, on the progress we had made up until that time, namely, the summer of 1970, in the joint programme, which had as one of its… Expand
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Since our work on corrin synthesis was intended to be a model study for the construction of the ligand system of vitamin B12 (cf. Part I of this series), the choice of an A/D component that wouldExpand
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The Ag+-induced reaction between N-cyclohexyl-α-chloro-propionaldonitrone and the two diastereomeric 2-butenes in liquid SO2 is a stereospecific cis-addition. The use ofExpand
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