The total synthesis of (+)-migrastatin.

  title={The total synthesis of (+)-migrastatin.},
  author={Christoph Gaul and Jon T Njardarson and Samuel J Danishefsky},
  journal={Journal of the American Chemical Society},
  volume={125 20},
The first total synthesis of (+)-migrastatin, a macrolide natural product with interesting antimetastatic properties, has been accomplished. Our concise and flexible approach utilizes a Lewis acid-catalyzed diene aldehyde condensation to install the three contiguous stereocenters and the trisubstituted (Z)-alkene of migrastatin. Construction of the two remaining stereocenters and incorporation of the glutarimide-containing side chain have been achieved via an anti-selective aldol reaction… CONTINUE READING