The total synthesis of (+)-elaeokanidine A: natural product or isolation artefact?

@inproceedings{Cuthbertson2015TheTS,
  title={The total synthesis of (+)-elaeokanidine A: natural product or isolation artefact?},
  author={James D. Cuthbertson and William P Unsworth and Catherine L. Moody and Richard J. K. Taylor},
  year={2015}
}
Abstract The first total synthesis of (+)-elaeokanidine A is reported. The synthesis features a formic acid-mediated cyclisation to access the indolizidine core and a double conjugate addition of ammonia to construct the piperidone unit. On the basis of 1 H NMR spectroscopic data, the relative stereochemistry of elaeokanidine A has been confirmed. Two isomeric species were also formed during the piperidone ring construction, which are potentially elaeokanidines B and C, although their… CONTINUE READING