The total length of spindle microtubules depends on the number of chromosomes present

@article{Nicklas1985TheTL,
  title={The total length of spindle microtubules depends on the number of chromosomes present},
  author={R. Bruce Nicklas and Gerald W. Gordon},
  journal={The Journal of Cell Biology},
  year={1985},
  volume={100},
  pages={1 - 7}
}
We extracted chromosomes by micromanipulation from Melanoplus differentialis spermatocytes, producing metaphase spindles with only one or a few chromosomes instead of the usual complement of 23. Cells with various numbers of chromosomes were prepared for electron microscopy, and spindle microtubule length was measured. A constant increment of microtubule length was lost upon the removal of each chromosome; we estimate that only approximately 40% of the original length would remain in the total… CONTINUE READING

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