The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats

@article{An2008TheTF,
  title={The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats},
  author={Lei An and You-zhi Zhang and Nengjiang J. Yu and Xin‐min Liu and Nan Zhao and Li Yuan and Hong-xia Chen and Yun-feng Li},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2008},
  volume={32},
  pages={1484-1490}
}
  • L. An, You-zhi Zhang, Yun-feng Li
  • Published 1 August 2008
  • Biology, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
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References

SHOWING 1-10 OF 53 REFERENCES
Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang
Antidepressant-like effects of the ethanolic extract of Xiaobuxin-Tang, a traditional Chinese herbal prescription in animal models of depression.
TLDR
The results suggested that the ethanolic extract of Xiaobuxin-Tang exerts antidepressant-like effect, and the extract at the effective doses for behavioral despair models, had no effect on spontaneous motor activity in mice.
Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
TLDR
Investigation of the effect of antidepressants on hippocampal neurogenesis in the adult rat using the thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing cells demonstrates that chronic antidepressant treatment significantly increases the number of BrdU-labeled cells in the dentate gyrus and hilus of the hippocampus.
Blockade of CRF1 or V1b receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression
TLDR
Results point to an important role of CRF and AVP in the regulation of dentate neurogenesis, and suggest that CRF1 and V1b receptor antagonists may affect plasticity changes in the hippocampal formation, as do clinically effective antidepressants.
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