The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats

  title={The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats},
  author={Lei An and You-zhi Zhang and Nengjiang J. Yu and Xin‐min Liu and Nan Zhao and Li Yuan and Hong-xia Chen and Yun-feng Li},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • L. An, You-zhi Zhang, Yun-feng Li
  • Published 1 August 2008
  • Biology, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
Total Flavonoids Extracted from Xiaobuxin-Tang on the Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis in Chronically Stressed Rats
The modulation of HPA axis produced by XBXT-2, including the inhibition of stress hormones levels and up-regulation of hippocampal GRs expression, may be an important mechanism underlying its antidepressant-like effect in chronically stressed rats.
Effects of SYJN, a Chinese herbal formula, on chronic unpredictable stress-induced changes in behavior and brain BDNF in rats.
Antioxidant activities of Dracocephalum tanguticum maxim extract and its up-regulation on the expression of neurotrophic factors in a rat model of permanent focal cerebral ischemia.
Findings suggested that DME has potential for treatment of ischemia-induced brain damage through stimulation of antioxidant activity and neurotrophic factor synthesis.
Danggui Buxue Tang, a simple Chinese formula containing Astragali Radix and Angelicae Sinensis Radix, stimulates the expressions of neurotrophic factors in cultured SH-SY5Y cells
This study supports that MAPK/Erk pathway acts as fundamental role in monitoring DBT-induced expression of neurotrophic factors in cultured human neuroblastoma cell.
Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain
This study is the first to demonstrate the rapid antidepressant effects of an herb medicine, offering an opportunity to improve therapy of depression.
Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions
A significant antidepressant-like effect of ZZHPD was demonstrated in mice which was related to monoaminergic system, ZH-BA and Zh-CH could be the active fractions responsible for the antidepressant effect ofZZH PD.
Flavonoids, derived from traditional Chinese medicines, show roles in the differentiation of neurons: possible targets in developing health food products.
The flavonoids from diverse herbal medicines have significant effects in different developmental stages of nervous systems, including neuronal stem cell differentiation, neurite outgrowth, and neuronal plasticity, implying that flavonoid are potential candidates for the development of health supplements in preventing birth defects and neuronal diseases.


Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang
Antidepressant-like effects of the ethanolic extract of Xiaobuxin-Tang, a traditional Chinese herbal prescription in animal models of depression.
The results suggested that the ethanolic extract of Xiaobuxin-Tang exerts antidepressant-like effect, and the extract at the effective doses for behavioral despair models, had no effect on spontaneous motor activity in mice.
Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
Investigation of the effect of antidepressants on hippocampal neurogenesis in the adult rat using the thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing cells demonstrates that chronic antidepressant treatment significantly increases the number of BrdU-labeled cells in the dentate gyrus and hilus of the hippocampus.
Blockade of CRF1 or V1b receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression
Results point to an important role of CRF and AVP in the regulation of dentate neurogenesis, and suggest that CRF1 and V1b receptor antagonists may affect plasticity changes in the hippocampal formation, as do clinically effective antidepressants.