The total burden of rare, non-synonymous exome genetic variants is not associated with childhood or late-life cognitive ability

Abstract

Human cognitive ability shows consistent, positive associations with fitness components across the life-course. Underlying genetic variation should therefore be depleted by selection, which is not observed. Genetic variation in general cognitive ability (intelligence) could be maintained by a mutation-selection balance, with rare variants contributing to… (More)
DOI: 10.1098/rspb.2014.0117

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Cite this paper

@inproceedings{Marioni2014TheTB, title={The total burden of rare, non-synonymous exome genetic variants is not associated with childhood or late-life cognitive ability}, author={Riccardo E. Marioni and Lars Penke and G A Davies and Jennifer E. Huffman and Caroline Hayward and Ian J. Deary}, booktitle={Proceedings. Biological sciences}, year={2014} }