The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.

@article{Rohde2003TheTP,
  title={The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.},
  author={John R. Rohde and Maria Elena Cardenas},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 2},
  pages={629-35}
}
The Tor pathway mediates cell growth in response to nutrient availability, in part by inducing ribosomal protein (RP) gene expression via an unknown mechanism. Expression of RP genes coincides with recruitment of the Esa1 histone acetylase to RP gene promoters. We show that inhibition of Tor with rapamycin releases Esa1 from RP gene promoters and leads to histone H4 deacetylation without affecting promoter occupancy by Rap1 and Abf1. Genetic and biochemical evidence identifies Rpd3 as the major… CONTINUE READING
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