The topomer search model: A simple, quantitative theory of two-state protein folding kinetics.

@article{Makarov2003TheTS,
  title={The topomer search model: A simple, quantitative theory of two-state protein folding kinetics.},
  author={Dmitrii E Makarov and Kevin W. Plaxco},
  journal={Protein science : a publication of the Protein Society},
  year={2003},
  volume={12 1},
  pages={
          17-26
        }
}
Most small, single-domain proteins fold with the uncomplicated, single-exponential kinetics expected for diffusion on a smooth energy landscape. Despite this energetic smoothness, the folding rates of these two-state proteins span a remarkable million-fold range. Here, we review the evidence in favor of a simple, mechanistic description, the topomer search model, which quantitatively accounts for the broad scope of observed two-state folding rates. The model, which stipulates that the search… CONTINUE READING

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