The topology design principles that determine the spatiotemporal dynamics of G-protein cascades.

  title={The topology design principles that determine the spatiotemporal dynamics of G-protein cascades.},
  author={Mikhail A Tsyganov and Walter Kolch and Boris N. Kholodenko},
  journal={Molecular bioSystems},
  volume={8 3},
Small monomeric G-proteins control cellular behavior, cycling between inactive GDP-bound and active GTP-bound states. Activating and deactivating transitions are regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), respectively. G-proteins can control different GEF and GAP activities, thereby creating GTPase signaling cascades. Here, we characterize all 128 different wiring topologies of two-layer cascades, which include feedforward/feedback… CONTINUE READING
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