The topology design principles that determine the spatiotemporal dynamics of G-protein cascades.

@article{Tsyganov2012TheTD,
  title={The topology design principles that determine the spatiotemporal dynamics of G-protein cascades.},
  author={Mikhail A Tsyganov and Walter Kolch and Boris N. Kholodenko},
  journal={Molecular bioSystems},
  year={2012},
  volume={8 3},
  pages={730-43}
}
Small monomeric G-proteins control cellular behavior, cycling between inactive GDP-bound and active GTP-bound states. Activating and deactivating transitions are regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), respectively. G-proteins can control different GEF and GAP activities, thereby creating GTPase signaling cascades. Here, we characterize all 128 different wiring topologies of two-layer cascades, which include feedforward/feedback… CONTINUE READING
Highly Cited
This paper has 17 citations. REVIEW CITATIONS
10 Citations
19 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 19 references

and W

  • B. N. Kholodenko, J. F. Hancoc
  • Kolch, Nat Rev Mol Cell Biol,
  • 2010

and H

  • H. Shankaran, D. L. Ippolito, W. B. Chrisler, H. Resat, N. Bollinger, L. K. Opresk
  • S. Wiley, Mol Syst Biol,
  • 2009

and R

  • S. R. Neve
  • Iyengar, J Biol Chem,
  • 2009

W

  • Z. Hilioti
  • Sabbagh, Jr., S. Paliwal, A. Bergmann, M. D…
  • 2008

and E

  • C. A. Athale, A. Dinarina, M. Mora-Coral, C. Pugieux, F. Nedele
  • Karsenti, Science,
  • 2008

and G

  • M. Sabouri-Ghomi, Y. Wu, K. Hah
  • Danuser, Curr Opin Cell Biol,
  • 2008

and K

  • J. R. Kim, Y. Yoo
  • H. Cho, Biophys J,
  • 2008

and L

  • Y. Mori, A. Jilkin
  • Edelstein-Keshet, Biophys J,
  • 2008

and M

  • C. I. Maeder, M. A. Hink, A. Kinkhabwala, R. Mayr, P. I. Bastiaen
  • Knop, Nat Cell Biol,
  • 2007

and P

  • S. D. Santos, P. J. Vervee
  • I. Bastiaens, Nat Cell Biol,
  • 2007

Similar Papers

Loading similar papers…