The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias

@article{Kozubek1999TheTO,
  title={The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias},
  author={Stanislav Kozubek and Em{\'i}lie Luk{\'a}{\vs}ov{\'a} and A. Mare{\vc}kov{\'a} and Magdalena Skaln{\'i}kov{\'a} and Michal Kozubek and Eva B{\'a}rtov{\'a} and V. Kroha and Eva Krahulcov{\'a} and Jana {\vS}lotov{\'a}},
  journal={Chromosoma},
  year={1999},
  volume={108},
  pages={426-435}
}
The neighborhood relationships of chromosomes can be of great importance for basic cellular processes such as gene expression or translocation induction. In this study, the topological organization of chromosomes 9 and 22 was investigated in cell nuclei of G0-phase lymphocytes. We found that the territories of both chromosomes are predominantly located in the central region of cell nuclei. In addition to this, chromosomes 9 and 22 were frequently associated in pairs detected as false-positive… CONTINUE READING
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Regional differences in the compaction of chromatin in human G 0 / G 1 interphase nuclei

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