The topical anti-inflammatory and analgesic properties of bromfenac in rodents

@article{Nolan2005TheTA,
  title={The topical anti-inflammatory and analgesic properties of bromfenac in rodents},
  author={J. Nolan and L. E. Wagner and C. E. Gathright and D. Stephens and L. Sancilio},
  journal={Agents and Actions},
  year={2005},
  volume={25},
  pages={77-85}
}
  • J. Nolan, L. E. Wagner, +2 authors L. Sancilio
  • Published 2005
  • Medicine
  • Agents and Actions
  • Bromfenac [2-amino-3-(4-bromobenzoyl) benzeneacetic acid sodium slat sesquihydrate] is an anti-inflammatory/analgesic agent that possesses potent topical activity in rats, guinea pigs, and mice. In rat models of acute (carrageenan paw edema) and chronic (adjuvant arthritis) inflammation, preparations of bromfenac at concentrations as low as 0.01–0.32% (0.01–0.32 mg bromfenac) produced significant anti-inflammatory activity when applied to the injected paw or to the backs of rats. In the acute… CONTINUE READING
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