The top2-5 mutant of yeast topoisomerase II encodes an enzyme resistant to etoposide and amsacrine.

@article{Jannatipour1993TheTM,
  title={The top2-5 mutant of yeast topoisomerase II encodes an enzyme resistant to etoposide and amsacrine.},
  author={Mehrdad Jannatipour and Yu Xiu Liu and John L Nitiss},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 25},
  pages={18586-92}
}
We have characterized a temperature-sensitive mutant in the yeast TOP2 gene that shows resistance to the anti-topoisomerase II agents amsacrine and etoposide. Cells carrying the top2-5 mutant have a minimum lethal concentration of amsacrine of greater than 100 micrograms/ml, compared to 10 micrograms/ml in isogenic wild-type cells, and a minimum lethal concentration of greater than 100 micrograms/ml etoposide, compared with 50 micrograms/ml for cells carrying wild-type topoisomerase II. We have… CONTINUE READING

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