The toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLCγ2 signalling cascade.

@article{Flker2014TheTR,
  title={The toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLCγ2 signalling cascade.},
  author={Knut F{\"a}lker and Kristin Klarstr{\"o}m-Engstr{\"o}m and Torbj{\"o}rn Bengtsson and Tomas L Lindahl and Magnus Greneg{\aa}rd},
  journal={Cellular signalling},
  year={2014},
  volume={26 2},
  pages={279-86}
}
The specific TLR2/1 complex activator Pam3CSK4 has been shown to provoke prominent activation and aggregation of human non-nucleated platelets. As Pam3CSK4-evoked platelet activation does not employ the major signalling pathway established in nucleated immune cells, we investigated if the TLR2/1 complex on platelets may initiate signalling pathways known to be induced by physiological agonists such as collagen via GPVI or thrombin via PARs. We found that triggering TLR2/1 complex-signalling… CONTINUE READING
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