The tolerability of dothiepin: A review of clinical studies between 1963 and 1990 in over 13,000 depressed patients

  title={The tolerability of dothiepin: A review of clinical studies between 1963 and 1990 in over 13,000 depressed patients},
  author={Stuart Donovan and L Dearden and L Richardson},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
Safety of Hypericum in Patients with Depression
Although hypericum was associated with fewer and milder ADRs in clinical trials than any of the other drugs, comparisons were difficult because of the different forms in which information was presented, and data on the safety of hypericum in overdose and on interactions with other drugs are as yet scarce.
Better tolerability of St. John's wort extract WS 5570 compared to treatment with SSRIs: a reanalysis of data from controlled clinical trials in acute major depression
WS 5570 was devoid of effects of sedation, anticholinergic reactions, gastrointestinal disturbances, and sexual dysfunction often found during treatment with SSRIs and other synthetic antidepressants.
Pisa syndrome (pleurothotonus) in a polytoxicomanic patient
  • H. Wölfl
  • Medicine, Psychology
    International journal of psychiatry in clinical practice
  • 2001
It is suggested that high doses of the tricyclic antidepressant dothiepin might be the most appropriate explanation for the appearance of Pisa syndrome in this patient.
Efficacy of Dosulepin in Tension Type Headache and Midfacial Pain a Randomised Controlled Study
  • Medicine, Psychology
  • 2020
From the study it has been found that subjects receiving dosulepin had more effective pain control and mood elevation then the subjects receiving placebo.
Psychopharmacological aspects of sleep in adults : primary focus on older adults.
Findings indicate most older adults do not have sleep complaints, but those who do are likely to have sleep problems due to physical reasons, and further research is necessary to establish the causes of poor sleep in old age.
Pisa syndrome (pleurothotonus) in a polytoxicomanic patient.
It is suggested that high doses of the tricyclic antidepressant dothiepin might be the most appropriate explanation for the appearance of Pisa syndrome in this patient.


A retrospective assessment of the long-term effects of dothiepin.
  • C. F. Herridge
  • Medicine, Psychology
    International pharmacopsychiatry
  • 1975
Dothiepin hydrochloride (Prothiaden) was found to be a well tolerated, safe and effective antidepressant with a special place in the treatment of chronic depressive states in inadequate personalities.
  • S. Sharma
  • Psychology, Medicine
    Indian journal of psychiatry
  • 1981
Findings show that the response to dotheipin was satisfactory and both treatments were equally effective in relieving symptoms of depression.
The outcome of dothiepin treatment in 1,900 depressed patients.
A good correlation was seen between the global scale and the Rockliffs depression scale; and also between the final mean Rockliff score and the number of patients stopping therapy due to recovery, and continuing treatment until recovery, at the final assessment.
Dothiepin hydrochloride: treatment efficacy and safety.
Dothiepin reduces the anxiety associated with some major depressive episodes and may be particularly helpful for treating anxious depressed patients and patients who have underlying cardiac disease or who are elderly.
A double-blind comparative study of alprazolam and dothiepin hydrochloride in the treatment of anxiety associated with depression.
Alprazolam should be considered for the treatment of anxiety associated with depression in patients for whom tricyclic antidepressant drugs are either contra-indicated or poorly tolerated, as both treatments produced equally satisfactory responses.
Clinical Trial Comparison of a Sustained Release Form of Amitriptyline with Dothiepin
  • T. Dorman
  • Psychology
    The Journal of international medical research
  • 1980
A double-blind between-group trial was undertaken in fifty depressed patients to compare the efficacy of a sustained release form of amitriptyline (Lentizol®) with dothiepin (Prothiaden®) over a 5-week period, with the mean responses at the end of the trial retaining the same relative positions as at the beginning.
A double-blind study of the efficacy and safety of dothiepin hydrochloride in the treatment of major depressive disorder.
Dothiepin was found to be an effective antidepressant drug associated with fewer side effects than amitriptyline in the treatment of depressed outpatients.
A controlled trial of antidepressant medication in elderly in-patients.
A multi-centre controlled trial of amitriptyline, dothiepin and mianserin in the treatment of depressive illness was undertaken in psychiatric inpatients over the age of 65, finding no treatment showed a significant superiority over the others, nor was there any difference in tolerance.
A General Practitioner Study of Dothiepin and Amitriptyline
Analysis of the results failed to demonstrate a statistically significant difference between the anti-depressant effect of the two drugs, but dothiepin was the favoured therapy in all assessments.
A single-blind comparative study of once daily dothiepin ("Prothiaden") and divided daily doses of amitriptyline.
  • J. Rees, P. Cryer
  • Medicine, Psychology
    Current medical research and opinion
  • 1976
The results showed that dothiepin caused a greater improvement than amitriptyline after 4 weeks of treatment as judged by depression scores, total scores and global assessments.