The tobacco mosaic virus particle: structure and assembly.

  title={The tobacco mosaic virus particle: structure and assembly.},
  author={Aaron Klug},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  volume={354 1383},
  • Aaron Klug
  • Published 1999 in
    Philosophical transactions of the Royal Society…
A short account is given of the physical and chemical studies that have led to an understanding of the structure of the tobacco mosaic virus particle and how it is assembled from its constituent coat protein and RNA. The assembly is a much more complex process than might have been expected from the simplicity of the helical design of the particle. The protein forms an obligatory intermediate (a cylindrical disk composed of two layers of protein units), which recognizes a specific RNA hairpin… CONTINUE READING