The tobacco etch viral 5' leader and poly(A) tail are functionally synergistic regulators of translation.

@article{Gallie1995TheTE,
  title={The tobacco etch viral 5' leader and poly(A) tail are functionally synergistic regulators of translation.},
  author={Daniel R Gallie and Robert L. Tanguay and Valerie L Leathers},
  journal={Gene},
  year={1995},
  volume={165 2},
  pages={233-8}
}
The 5' cap (m7GpppN) and the poly(A) tail of eukaryotic mRNAs work in concert to establish an efficient level of translation in vivo. Nevertheless, several mRNAs naturally lack a cap or a poly(A) tail. Determining how these messages effectively compete for the translational machinery not only reveals alternative mechanisms for translational competence, but can also underscore similarities between alternative mechanisms and the standard cap/poly(A) tail interaction. The genomic RNA of tobacco… CONTINUE READING