The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12.

@article{Royden1987TheTL,
  title={The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12.},
  author={C S Royden and Vincenzo Pirrotta and Lily Yeh Jan},
  journal={Cell},
  year={1987},
  volume={51 2},
  pages={165-73}
}
The tko (technical knockout) mutation is one of a family of behavioral mutations that cause "bang sensitivity" in D. melanogaster. Using P-element-mediated transformation, we show that a 3.1 kb piece of genomic DNA complements tko. This fragment contains only one complete transcript, 0.68 kb in length. This transcript is abundantly expressed through all stages of the life cycle, and we have isolated cDNAs corresponding to this transcript. Their sequence implies a protein product composed of 140… CONTINUE READING