The tissue transglutaminase activity does not strengthen cell adhesion during mechanical stretch

@article{Karamanoglu2001TheTT,
  title={The tissue transglutaminase activity does not strengthen cell adhesion during mechanical stretch},
  author={M. Karamanoglu},
  journal={2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society},
  year={2001},
  volume={3},
  pages={2961-2962 vol.3}
}
  • M. Karamanoglu
  • Published 25 October 2001
  • Computer Science
  • 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Tissue transglutaminase activity (tTGA) has been shown to be important in cell adhesion to an extracellular matrix (EM). However, it is not well know if tTGA improves cell adhesion during mechanical strains imposed on the EM. We have compared the adherence properties of NIH 3T3-fibroblast cell line on fibronectin (FN) and on an EM that lacks the 42KD tTG-binding site. The cells were plated on silicone membranes and were stretched 10% also. Results indicate cell loose their morphology in the… 

References

Tissue Transglutaminase Is an Integrin-Binding Adhesion Coreceptor for Fibronectin
TLDR
It is demonstrated that tissue transglutaminase mediates the interaction of integrins with fibronectin, thereby acting as an integrin-associated coreceptor to promote cell adhesion and spreading.