The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: interactions with the osteocalcin gene promoter.

@article{Merriman1995TheTN,
  title={The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: interactions with the osteocalcin gene promoter.},
  author={Harold L. Merriman and Andre J van Wijnen and Scott W. Hiebert and Joseph P. Bidwell and Edward G. Fey and Jane B Lian and Janet L Stein and Gary S Stein},
  journal={Biochemistry},
  year={1995},
  volume={34 40},
  pages={13125-32}
}
The nuclear matrix protein, NMP-2, was originally identified as an osteoblast-specific DNA-binding complex localized exclusively to the nuclear matrix. NMP-2 was shown to recognize two binding sites, site A (nt-605 to -599) and site B (nt -441 to -435), in the rat bone-specific osteocalcin gene promoter. This study shows that the NMP-2 binding sites A and B as well as a third NMP-2 binding site (nt -135 to -130) constitute a consensus sequence, ATGCTGGT, and represent an AML-1 recognition motif… CONTINUE READING

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