The tissue-specific expression of the thyroglobulin gene requires interaction between thyroid-specific and ubiquitous factors.

@article{Sinclair1990TheTE,
  title={The tissue-specific expression of the thyroglobulin gene requires interaction between thyroid-specific and ubiquitous factors.},
  author={Andrew J. Sinclair and Renata I Lonigro and D Civitareale and Lina Ghibelli and Roberto Di Lauro},
  journal={European journal of biochemistry},
  year={1990},
  volume={193 2},
  pages={311-8}
}
Thyroid-specific expression of the rat thyroglobulin gene is mediated by transcriptional control. Sufficient DNA sequence information to confer thyroid-specific expression to a heterologous gene is contained between positions -168 and +39. DNA-binding studies have demonstrated that this region interacts with two thyroid-specific factors (TTF-1 and TTF-2), and a ubiquitous factor (UFA). Here we have characterized three elements within the promoter, A, K, and C, which are important for promoter… CONTINUE READING

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