The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.

@article{Nagai2004TheTP,
  title={The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.},
  author={Taku Nagai and Kiyofumi Yamada and Masako Yoshimura and Kazuhiro Ishikawa and Yoshiaki Miyamoto and Kazuki Hashimoto and Yukihiro Noda and Atsumi Nitta and Toshitaka Nabeshima},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 10},
  pages={
          3650-5
        }
}
Tissue plasminogen activator (tPA) is a serine protease that catalyzes the conversion of plasminogen (plg) to plasmin, which in turn functions to degrade extracellular matrix proteins in the central nervous system. The tPA-plasmin system plays a role in synaptic plasticity and remodeling. Here we show that this protease system participates in the rewarding effects of morphine by acutely regulating morphine-induced dopamine release in the nucleus accumbens (NAcc). A single morphine treatment… CONTINUE READING
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