The tissue factor pathway in disseminated intravascular coagulation.

@article{sterud2001TheTF,
  title={The tissue factor pathway in disseminated intravascular coagulation.},
  author={Bjarne \Osterud and Eirik Bj\orklid},
  journal={Seminars in thrombosis and hemostasis},
  year={2001},
  volume={27 6},
  pages={605-17}
}
In most instances, tissue factor (TF) exposed to the circulation is the sole culprit underlying the initiation of disseminated intravascular coagulation (DIC), although notable exceptions because of a more direct activation of the coagulation system, by snake venoms, for example, do occur. Peripheral monocytes and subendothelial structures are the potential sources of such TF; in the former, TF emerges on the cell surface on synthesis induction and in the latter it becomes available subsequent… CONTINUE READING

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