The timing of channel opening during miniature end-plate currents

@article{Cohen1981TheTO,
  title={The timing of channel opening during miniature end-plate currents},
  author={I. Cohen and W. Kloot and D. Attwell},
  journal={Brain Research},
  year={1981},
  volume={223},
  pages={185-189}
}
  • I. Cohen, W. Kloot, D. Attwell
  • Published 1981
  • Medicine
  • Brain Research
  • Many chemical transmitters act by opening channels with exponentially distributed life-times. We present a way to analyze a synaptic current in terms of its component channels. We can estimate the numbers and times of channel opening within the synaptic current. This approach is used to study miniature end-plate currents (m.e.p.c.s) at the frog neuromuscular junction. The results support the idea that some transmitter rebinds after dissociation from post-synaptic receptors, and suggest that the… CONTINUE READING
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    References

    SHOWING 1-10 OF 10 REFERENCES
    Voltage-dependence of drug-induced conductance in frog neuromuscular junction.
    • E. Neher, B. Sakmann
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1975
    • 139
    • PDF
    Single-channel currents recorded from membrane of denervated frog muscle fibres
    • 2,188
    Active phase of frog's end-plate potential.
    • 338
    • PDF
    A quantitative description of end‐plate currents
    • 512
    The binding of acetylcholine to receptors and its removal from the synaptic cleft
    • 544
    The statistical nature of the acetylcholine potential and its molecular components
    • 889
    • PDF