The timing of calcium action during neuromuscular transmission.

  title={The timing of calcium action during neuromuscular transmission.},
  author={Bernard Katz and Ricardo Miledi},
  journal={The Journal of physiology},
  volume={189 3},
1. When a nerve-muscle preparation is paralysed by tetrodotoxin, brief depolarizing pulses applied to a motor nerve ending cause packets of acetylcholine to be released and evoke end-plate potentials (e.p.p.s), provided calcium ions are present in the extracellular fluid.2. By ionophoretic discharge from a 1 M-CaCl(2) pipette, it is possible to produce a sudden increase in the local calcium concentration at the myoneural junction, at varying times before or after the depolarizing pulse.3. A… CONTINUE READING