The time to reach steady state after the administration of intravenous bolus, constant infusion, and oral immediate-release and sustained-release preparations.

Abstract

Based on one-compartment pharmacokinetic model, the equations to calculate the specific fractional steady-state of drug level achieved at any time (FSS) after administration of intravenous bolus, constant infusion, and oral immediate-release preparations are reviewed. Also the equation to calculate FSS after administering an oral sustained-release dosage… (More)

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