The time-dependent effects of midazolam on regional cerebral glucose metabolism in rats.


BACKGROUND Midazolam has hypnotic and sedative activities, which may be mediated by different neuronal structures. We investigated the time course effect of a hypnotic dose of midazolam on conscious motor behavior and on patterns of brain metabolism. METHODS Loss of nociceptive reflexes and impairment of spontaneous locomotor activity were used as indices… (More)
DOI: 10.1213/ane.0b013e31816a64a8


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