The time course of nonchronic major depressive disorder. Uniformity across episodes and samples. National Institute of Mental Health Collaborative Program on the Psychobiology of Depression--Clinical Studies.

@article{Coryell1994TheTC,
  title={The time course of nonchronic major depressive disorder. Uniformity across episodes and samples. National Institute of Mental Health Collaborative Program on the Psychobiology of Depression--Clinical Studies.},
  author={William H. Coryell and Hagop Souren Akiskal and Andrew C. Leon and George Winokur and Jack D. Maser and Timothy I. Mueller and Martin B. Keller},
  journal={Archives of general psychiatry},
  year={1994},
  volume={51 5},
  pages={405-10}
}
BACKGROUND Most natural history studies of affective disorders have emphasized the prediction of eventual recovery. Little is known of changes over time in the immediate probability of recovery. METHODS To identify regularities in the timing of recovery from nonbipolar major depressive disorders, we considered only episodes that began during follow-up to increase the accuracy with which onsets were timed and to limit the study sample to individuals who had a demonstrably episodic course. Five… CONTINUE READING

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