The time course of delivery of furosemide into urine: an independent determinant of overall response.

@article{Kaojarern1982TheTC,
  title={The time course of delivery of furosemide into urine: an independent determinant of overall response.},
  author={Sming Kaojarern and Brian Day and Dr D. Craig Brater},
  journal={Kidney international},
  year={1982},
  volume={22 1},
  pages={69-74}
}
After an oral or intravenous dose of furosemide, there is considerable interindividual variability in the amount of unchanged drug delivered into the urine. On average, approximately half as much reaches the intraluminal site of action with an oral compared to an intravenous dose. However, the natriuretic response to the same dose administered by either route is virtually the same. Similarly, after pretreatment with probenecid, the same total amount of furosemide in urine causes a greater… CONTINUE READING