The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination.

@article{Moens2002TheTC,
  title={The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination.},
  author={Peter B. Moens and Nadine Kolas and Madalena Tarsounas and Edyta Marcon and Paula E Cohen and Barbara Spyropoulos},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 8},
  pages={
          1611-22
        }
}
During mouse meiosis, the early prophase RAD51/DMC1 recombination protein sites, which are associated with the chromosome cores and which serve as markers for ongoing DNA-DNA interactions, are in ten-fold excess of the eventual reciprocal recombinant events. Most, if not all, of these early interactions are eliminated as prophase progresses. The manner in which these sites are eliminated is the focus of this investigation. We report that these sites acquire replication protein A, RPA and the… CONTINUE READING

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