The tight-skin mouse: an animal model of inherited emphysema.

@article{Rossi1980TheTM,
  title={The tight-skin mouse: an animal model of inherited emphysema.},
  author={G. Rossi and G. Hunninghake and S. Szapiel and J. Gadek and J. Fulmer and O. Kawanami and V. Ferrans and R. Crystal},
  journal={Bulletin europeen de physiopathologie respiratoire},
  year={1980},
  volume={16 Suppl},
  pages={
          157-66
        }
}
The tight-skin mouse is a newly described mutant characterized in heterozygotes (Tsk/ +) by generalized connective tissue defects. Since the Tsk/ + mouse also has an enlarged thorax with enlarged lungs, features often found in people with destructive lung diseases, this animal was evaluated as a possible model of pulmonary emphysema. Morphologically, Tsk/ + mouse lungs are characterized by enlarged airspaces, distention of alveoli, and destruction of alveolar septa. In addition, there are… Expand
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Marfan-Like Skeletal Phenotype in the Tight Skin (Tsk) Mouse
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Alpha-1 Antitrypsin Investigations Using Animal Models of Emphysema.
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Development of spinal deformities in the tight-skin mouse
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In vivo assessment of emphysema in mice by high resolution X‐ray microtomography
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SHORT TECHNICAL NOTE
  • 21

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