The thyroid hormone receptor functions as a ligand-operated developmental switch between proliferation and differentiation of erythroid progenitors.

@article{Bauer1998TheTH,
  title={The thyroid hormone receptor functions as a ligand-operated developmental switch between proliferation and differentiation of erythroid progenitors.},
  author={Annie Bauer and Wolfgang Mikulits and Gerda Lagger and Gabriele Stengl and Gerald Brosch and Hartmut Beug},
  journal={The EMBO journal},
  year={1998},
  volume={17 15},
  pages={4291-303}
}
The avian erythroblastosis virus (AEV) oncoprotein v-ErbA represents a mutated, oncogenic thyroid hormone receptor alpha (c-ErbA/ TRalpha). v-ErbA cooperates with the stem cell factor-activated, endogenous receptor tyrosine kinase c-Kit to induce self-renewal and to arrest differentiation of primary avian erythroblasts, the AEV transformation target cells. In this cooperation, v-ErbA substitutes for endogenous steroid hormone receptor function required for sustained proliferation of non… CONTINUE READING

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Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor

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