The thyroid cancer PAX8-PPARG fusion protein activates Wnt/TCF-responsive cells that have a transformed phenotype.

@article{VuPhan2013TheTC,
  title={The thyroid cancer PAX8-PPARG fusion protein activates Wnt/TCF-responsive cells that have a transformed phenotype.},
  author={Dang Vu-Phan and Vladimir Grachtchouk and Jingcheng Yu and Lesley A. Colby and Max S. Wicha and Ronald J Koenig},
  journal={Endocrine-related cancer},
  year={2013},
  volume={20 5},
  pages={
          725-39
        }
}
A chromosomal translocation results in the production of a paired box 8-peroxisome proliferator-activated receptor gamma (PAX8-PPARG) fusion protein (PPFP) in ∼35% of follicular thyroid carcinomas. To examine the role of PPFP in thyroid oncogenesis, the fusion protein was stably expressed in the non-transformed rat thyroid cell line PCCL3. PPFP conferred on PCCL3 cells the ability to invade through Matrigel and to form colonies in anchorage-independent conditions. PPFP also increased the… CONTINUE READING

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