The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice.

Abstract

Arachidonic acid metabolites, some of which may activate thromboxane A(2) receptors (TPr) and contribute to the development of diabetes complications, including nephropathy, are elevated in diabetes. This study determined the effect of blocking TPr with S18886 or inhibiting cyclooxygenase with aspirin on oxidative stress and the early stages of nephropathy… (More)

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@article{Xu2006TheTR, title={The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice.}, author={Shanqin Xu and Bingbing Jiang and Karlene A Maitland and Hossein Bayat and Jiali Gu and Jerry L Nadler and Stefano Corda and Gilbert Lavielle and Tony J. Verbeuren and Adriana Zuccollo and Richard Cohen}, journal={Diabetes}, year={2006}, volume={55 1}, pages={110-9} }