The thromboxane/endoperoxide receptor (TP): the common villain.

@article{Fltou2010TheTR,
  title={The thromboxane/endoperoxide receptor (TP): the common villain.},
  author={Michel F{\'e}l{\'e}tou and Paul Michel Vanhoutte and Tony J. Verbeuren},
  journal={Journal of cardiovascular pharmacology},
  year={2010},
  volume={55 4},
  pages={317-32}
}
The stimulation of thromboxane/endoperoxide receptors (TP) elicits diverse physiological/pathophysiological reactions, including platelet aggregation and contraction of vascular smooth muscle. Furthermore, the activation of endothelial TP promotes the expression of adhesion molecules and favors adhesion and infiltration of monocytes/macrophages. In various cardiovascular diseases, endothelial dysfunction is predominantly the result of the release of endothelium-derived contracting factors that… CONTINUE READING

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