The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi.

@article{Frazier1999TheTR,
  title={The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi.},
  author={William A. Frazier and Author Gao and Julie Dimitry and Jin-Ho Chung and Eric J. Brown and F P Lindberg and Maurine E. Linder},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 13},
  pages={8554-60}
}
Integrin-associated protein (IAP; CD47) is a thrombospondin receptor that forms a signaling complex with beta3 integrins resulting in enhanced alphavbeta3-dependent cell spreading and chemotaxis and, in platelets, alphaIIbbeta3-dependent spreading and aggregation. These actions of CD47 are all specifically abrogated by pertussis toxin treatment of cells. Here we report that CD47, its beta3 integrin partner, and Gi proteins form a stable, detergent-soluble complex that can be recovered by… CONTINUE READING
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