The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO.

@article{Chou2012TheTP,
  title={The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO.},
  author={Fu-Sheng Chou and Andrea Griesinger and Mark E. Wunderlich and Shan Lin and Kevin A. Link and Mahesh Shrestha and Susumu Goyama and Benjamin E Mizukawa and Shuhong Shen and Guido Marcucci and James C. Mulloy},
  journal={Blood},
  year={2012},
  volume={120 4},
  pages={709-19}
}
AML1-ETO (AE) is a fusion product of translocation (8;21) that accounts for 40% of M2 type acute myeloid leukemia (AML). In addition to its role in promoting preleukemic hematopoietic cell self-renewal, AE represses DNA repair genes, which leads to DNA damage and increased mutation frequency. Although this latter function may promote leukemogenesis, concurrent p53 activation also leads to an increased baseline apoptotic rate. It is unclear how AE expression is able to counterbalance this… CONTINUE READING

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