The thrombopenic effect of ellagic acid in the rat. Another model of platelet stimulation "in vivo".

@article{Damas1987TheTE,
  title={The thrombopenic effect of ellagic acid in the rat. Another model of platelet stimulation "in vivo".},
  author={Jacques Damas and G. Remacle-Volon},
  journal={Thrombosis research},
  year={1987},
  volume={45 2},
  pages={
          153-63
        }
}
In the rat, intravenous injection of large doses (30 mg/Kg) of ellagic acid (EA) induced a decrease in the plasma level of fibrinogen and in the blood platelet content and an increase of the activated partial thromboplastin time. The long-lasting thrombocytopenia was inhibited by heparin (4 mg/Kg), defibrase (20 U/Kg), clocoumarol (4 mg/Kg) and CCI 17810 (120 mg/Kg). It was not inhibited by aspirin (90 mg/Kg), indomethacin (8 mg/Kg), ketoprofen (4-10 mg/Kg), epsilon-aminocaproic acid (150 mg/Kg… Expand
Studies on the vascular and hematological changes induced by ellagic acid in rats
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It is concluded that the vascular changes induced by blood coagulation with ellagic acid resulted mainly from kinin formation. Expand
Some cardiovascular and hematological changes induced in the rat by activation of Hageman factor with ellagic acid.
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It is suggested that combining ellagic acid with a known nonspecific COX inhibitor such as ketorolac may cause a significant decrease in platelet activity and an increase in blood loss. Expand
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