The thrombopenic effect of ellagic acid in the rat. Another model of platelet stimulation "in vivo".

@article{Damas1987TheTE,
  title={The thrombopenic effect of ellagic acid in the rat. Another model of platelet stimulation "in vivo".},
  author={Jacques Damas and Gaby Remacle-Volon},
  journal={Thrombosis research},
  year={1987},
  volume={45 2},
  pages={153-63}
}
In the rat, intravenous injection of large doses (30 mg/Kg) of ellagic acid (EA) induced a decrease in the plasma level of fibrinogen and in the blood platelet content and an increase of the activated partial thromboplastin time. The long-lasting thrombocytopenia was inhibited by heparin (4 mg/Kg), defibrase (20 U/Kg), clocoumarol (4 mg/Kg) and CCI 17810 (120 mg/Kg). It was not inhibited by aspirin (90 mg/Kg), indomethacin (8 mg/Kg), ketoprofen (4-10 mg/Kg), epsilon-aminocaproic acid (150 mg/Kg… CONTINUE READING